ETHYL DIAZOACETATE
Manufacturer
Reddy 'N' Reddy Pharmaceuticals,
Hyderabad
Manufacturer
Reddy 'N' Reddy Pharmaceuticals,
Hyderabad
1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
1.1 Product identifiers
Product name : Ethyl diazoacetate
Other name :2-diazoacetic acid ethyl ester
CAS-No. : 623-73-4
molecular Formula : C4H6N2O2 (N=N=CHC(O)OC2H5)
discovered by Theodor Curtius in 1883
Other name :2-diazoacetic acid ethyl ester
CAS-No. : 623-73-4
molecular Formula : C4H6N2O2 (N=N=CHC(O)OC2H5)
discovered by Theodor Curtius in 1883
2. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: clear, liquid
b) Melting point/freezing point : -22 °C
c) Initial boiling point and boiling range 140 - 141 °C at 960 hPa
d) Flash point 47 °C - closed cup
e) Relative density 1,085 g/cm3 at 25 °C
f) Water solubility slightly soluble
.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Molecular Weight : 114,10 g/mol
Component
|
concentration
|
Ethyl diazoacetate
| |
CAS-No: 623-73-4
EC-No. 210-810-8 |
50 - 100 %
|
Methylene chloride
| |
CAS-No. 75-09-2
EC-No. 200-838-9 Index-No. 602-004-00-3 |
20 - 25 %
|
4. FIRST AID MEASURES
4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
Dichloromethane is metabolized in the body producing carbon monoxide which increases and sustains carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity of the blood., Acts as a simple asphyxiant by displacing air., Acute symptoms of overexposure include:, Difficulty in breathing, Headache, Dizziness, Prolonged or repeated exposure to skin causes defatting and dermatitis., Contact with eyes can cause:, Redness, Effects due to ingestion may include:, Gastrointestinal disturbance, Central nervous system depression, Paresthesia., Convulsions, pulmonary edema, Symptoms may be delayed., Increased liver enzymes. (Ethyl diazoacetate)
Dichloromethane is metabolized in the body producing carbon monoxide which increases and sustains carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity of the blood., Acts as a simple asphyxiant by displacing air., Acute symptoms of overexposure include:, Difficulty in breathing, Headache, Dizziness, Prolonged or repeated exposure to skin causes defatting and dermatitis., Contact with eyes can cause:, Redness, Effects due to ingestion may include:, Gastrointestinal disturbance, Central nervous system depression, Paresthesia., Convulsions, pulmonary edema, Symptoms may be delayed., Increased liver enzymes. (Ethyl diazoacetate)
5. FIREFIGHTING MEASURES
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas
Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas
5.3 Advice for fire fighters
Wear self contained breathing apparatus for fire fighting if necessary.
Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.
Use water spray to cool unopened containers.
6. ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations
7. HANDLING AND STORAGE
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Recommended storage temperature: 2 - 8 °C
Recommended storage temperature: 2 - 8 °C
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Exposure controls
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
9. HAZARDS IDENTIFICATION
9.1 Classification of the substance or mixture
Classification according to Regulation Flammable liquids (Category 3)Acute toxicity, Oral (Category 4)Skin irritation (Category 2)Carcinogenicity (Category 2)
Classification according to EU Directives Flammable. Harmful if swallowed. Limited evidence of a carcinogenic effect. Heating may cause an explosion.
9.2 Other hazards
Heating may cause an explosion
Heating may cause an explosion
10. STABILITY AND REACTIVITY
10.1 Conditions to avoid
Heat, flames and sparks.
Heat, flames and sparks.
10.2 Incompatible materials
Strong oxidizing agents, Alkali metals, Aluminium, Bases, Sulfuric acid
Strong oxidizing agents, Alkali metals, Aluminium, Bases, Sulfuric acid
11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 400 mg/kg (Ethyl diazoacetate)
Acute toxicity
LD50 Oral - rat - 400 mg/kg (Ethyl diazoacetate)
LD50 Intravenous - rat - 280 mg/kg (Ethyl diazoacetate)
Remarks: Behavioral:Somnolence (general depressed activity). Lungs, Thorax, or Respiration:Dyspnea.
Potential health effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion Harmful if swallowed.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes eye irritation.
Signs and Symptoms of Exposure
Dichloromethane is metabolized in the body producing carbon monoxide which increases and sustains carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity of the blood., Acts as a simple asphyxiant by displacing air., Acute symptoms of overexposure include:, Difficulty in breathing, Headache, Dizziness, Prolonged or repeated exposure to skin causes defatting and dermatitis., Contact with eyes can cause:, Redness, Effects due to ingestion may include:, Gastrointestinal disturbance, Central nervous system depression, Paresthesia., Convulsions, pulmonary edema, Symptoms may be delayed., Increased liver enzymes. (Ethyl diazoacetate)
Dichloromethane is metabolized in the body producing carbon monoxide which increases and sustains carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity of the blood., Acts as a simple asphyxiant by displacing air., Acute symptoms of overexposure include:, Difficulty in breathing, Headache, Dizziness, Prolonged or repeated exposure to skin causes defatting and dermatitis., Contact with eyes can cause:, Redness, Effects due to ingestion may include:, Gastrointestinal disturbance, Central nervous system depression, Paresthesia., Convulsions, pulmonary edema, Symptoms may be delayed., Increased liver enzymes. (Ethyl diazoacetate)
12. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.
Dispose of as unused product.
